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Immunotherapy: Metal–Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH (Adv. Mater. 19/2020)
Author(s) -
Ploetz Evelyn,
Zimpel Andreas,
Cauda Valentina,
Bauer David,
Lamb Don C.,
Haisch Christoph,
Zahler Stefan,
Vollmar Angelika M.,
Wuttke Stefan,
Engelke Hanna
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202070147
Subject(s) - pyroptosis , endocytosis , materials science , extracellular , lysis , nanoparticle , nanotechnology , programmed cell death , immunotherapy , biophysics , cell , immune system , microbiology and biotechnology , apoptosis , chemistry , biology , biochemistry , immunology
In article number 1907267, Stefan Wuttke, Hanna Engelke, and co‐workers describe how lipid‐coated metal–organic framework (MOF) nanoparticles are taken up by cells via endocytosis. Once inside the cell, the MOF nanoparticles are degraded depending on the extracellular pH. The degradation product leads to pyroptosis—a programmed cell death involving the immune system, in which the cell membrane is perforated with pores leading to cell lysis. Ultimately, the nanoparticles may be used for immunotherapy.