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RNA Delivery: A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes (Adv. Mater. 12/2020)
Author(s) -
Ramishetti Srinivas,
HazanHalevy Inbal,
Palakuri Ramesh,
Chatterjee Sushmita,
Naidu Gonna Somu,
Dammes Niels,
Freilich Inbar,
Kolik Shmuel Luba,
Danino Dganit,
Peer Dan
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202070093
Subject(s) - gene silencing , in vivo , in vitro , rna interference , solid lipid nanoparticle , gene delivery , rna , linker , drug delivery , materials science , nanoparticle , immune system , nanotechnology , biology , microbiology and biotechnology , gene , biochemistry , genetic enhancement , immunology , computer science , operating system
In article number 1906128, Dan Peer and co‐workers describe the design and synthesis of novel ionizable lipids based on a linker strategy. The lipids are formulated into lipid nanoparticles and are screened for their gene silencing efficacies in cell‐culture models in vitro. Potent lipids are identified and analyzed for in vivo gene silencing efficacy in murine primary lymphocytes. Furthermore, no liver toxicity and no potential immune activation are observed in mice.