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Bone Healing: In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing (Adv. Mater. 8/2020)
Author(s) -
Zeng Yuze,
Shih YuRu V.,
Baht Gurpreet S.,
Varghese Shyni
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202070059
Subject(s) - biomaterial , bone healing , materials science , wound healing , in vivo , adenosine , microbiology and biotechnology , biomedical engineering , nanotechnology , chemistry , medicine , biology , immunology , biochemistry , anatomy
In article number 1906022, Shyni Varghese and co‐workers describe the application of a designer biomaterial “bandage” at the site of a bone injury to sequester and localize innate pro‐healing signaling molecules that promote vascularization and healing. The biomaterial‐assisted sequestration of adenosine leverages the transient surge of extracellular adenosine following injury to prolong local adenosine signaling, offering a versatile solution to utilizing adenosine as a potential therapeutic for tissue repair.