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Advances in Application of Azobenzene as a Trigger in Biomedicine: Molecular Design and Spontaneous Assembly
Author(s) -
Cheng HongBo,
Zhang Shuchun,
Qi Ji,
Liang XingJie,
Yoon Juyoung
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202007290
Subject(s) - azobenzene , materials science , nanotechnology , stimulus (psychology) , molecular switch , molecule , polymer , chemistry , organic chemistry , psychology , composite material , psychotherapist
Azobenzene is a well‐known derivative of stimulus‐responsive molecular switches and has shown superior performance as a functional material in biomedical applications. The results of multiple studies have led to the development of light/hypoxia‐responsive azobenzene for biomedical use. In recent years, long‐wavelength‐responsive azobenzene has been developed. Matching the longer wavelength absorption and hypoxia‐response characteristics of the azobenzene switch unit to the bio‐optical window results in a large and effective stimulus response. In addition, azobenzene has been used as a hypoxia‐sensitive connector via biological cleavage under appropriate stimulus conditions. This has resulted in on/off state switching of properties such as pharmacology and fluorescence activity. Herein, recent advances in the design and fabrication of azobenzene as a trigger in biomedicine are summarized.