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The Microbiome Meets Nanotechnology: Opportunities and Challenges in Developing New Diagnostic Devices
Author(s) -
FuentesChust Celia,
Parolo Claudio,
Rosati Giulio,
Rivas Lourdes,
PerezToralla Karla,
Simon Stéphanie,
Lecuona Itziar,
Junot Christophe,
Trebicka Jonel,
Merkoçi Arben
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202006104
Subject(s) - microbiome , context (archaeology) , nanotechnology , data science , systems engineering , personalized medicine , risk analysis (engineering) , emerging technologies , engineering ethics , computer science , materials science , engineering , business , biology , bioinformatics , paleontology
Monitoring of the human microbiome is an emerging area of diagnostics for personalized medicine. Here, the potential of different nanomaterials and nanobiosensing technologies is reviewed for the development of novel diagnostic devices for the detection and measurement of microbiome‐related biomarkers. Moreover, the current and future landscape of microbiome‐based diagnostics is defined by exploring the advantages and disadvantages of current nanotechnology‐based approaches, especially in the context of developing point‐of‐care (PoC) devices that would meet the international guidelines known as REASSURED (Real‐time connectivity; Ease of specimen collection; Affordability; Sensitivity; Specificity; User‐friendliness; Rapid & robust operation; Equipment‐free; and Deliverability). Finally, the strategies of the latest international scientific consortia working in this field are analyzed, the current microbiome diagnostics market are reported and the principal ethical, legal, and societal issues related to microbiome R&D and innovation are discussed.