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Ultrasonic Interfacial Engineering of Red Phosphorous–Metal for Eradicating MRSA Infection Effectively
Author(s) -
Guan Wei,
Tan Lei,
Liu Xiangmei,
Cui Zhenduo,
Zheng Yufeng,
Yeung Kelvin Wai Kwok,
Zheng Dong,
Liang Yanqin,
Li Zhaoyang,
Zhu Shengli,
Wang Xianbao,
Wu Shuilin
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202006047
Subject(s) - materials science , cavitation , metal , sonodynamic therapy , nanotechnology , electron , ultrasonic sensor , ultrasound , biophysics , biomedical engineering , metallurgy , physics , mechanics , acoustics , biology , medicine , quantum mechanics
Sonodynamic therapy (SDT) is considered to be a potential treatment for various diseases including cancers and bacterial infections due to its deep penetration ability and biosafety, but its SDT efficiency is limited by the hypoxia environment of deep tissues. This study proposes creating a potential solution, sonothermal therapy, by developing the ultrasonic interfacial engineering of metal–red phosphorus (RP), which has an obviously improved sonothermal ability of more than 20 °C elevation under 25 min of continuous ultrasound (US) excitation as compared to metal alone. The underlying mechanism is that the mechanical energy of the US activates the motion of the interfacial electrons. US‐induced electron motion in the RP can efficiently transfer the US energy into phonons in the forms of heat and lattice vibrations, resulting in a stronger US absorption of metal–RP. Unlike the nonspecific heating of the cavitation effect induced by US, titanium–RP can be heated in situ when the US penetrates through 2.5 cm of pork tissue. In addition, through a sonothermal treatment in vivo, bone infection induced by multidrug‐resistant Staphylococcus aureus (MRSA) is successfully eliminated in under 20 min of US without tissue damage. This work provides a new strategy for combating MRSA by strong sonothermal therapy through US interfacial engineering.