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Bioinspired Spiky Peroxidase‐Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization
Author(s) -
Yang Ye,
Wu Xizheng,
Ma Lang,
He Chao,
Cao Sujiao,
Long Yanping,
Huang Jianbo,
Rodriguez Raul D.,
Cheng Chong,
Zhao Changsheng,
Qiu Li
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202005477
Subject(s) - catalysis , peroxidase , bacteria , pathogenic bacteria , radical , sterilization (economics) , point of delivery , materials science , broad spectrum , reactive oxygen species , nanotechnology , microbiology and biotechnology , combinatorial chemistry , biology , chemistry , enzyme , biochemistry , agronomy , genetics , monetary economics , economics , foreign exchange market , foreign exchange
Besides the pandemic caused by the coronavirus outbreak, many other pathogenic microbes also pose a devastating threat to human health, for instance, pathogenic bacteria. Due to the lack of broad‐spectrum antibiotics, it is urgent to develop nonantibiotic strategies to fight bacteria. Herein, inspired by the localized “capture and killing” action of bacteriophages, a virus‐like peroxidase‐mimic (V‐POD‐M) is synthesized for efficient bacterial capture (mesoporous spiky structures) and synergistic catalytic sterilization (metal–organic‐framework‐derived catalytic core). Experimental and theoretical calculations show that the active compound, MoO 3 , can serve as a peroxo‐complex‐intermediate to reduce the free energy for catalyzing H 2 O 2 , which mainly benefits the generation of •OH radicals. The unique virus‐like spikes endow the V‐POD‐M with fast bacterial capture and killing abilities (nearly 100% at 16 µg mL –1 ). Furthermore, the in vivo experiments show that V‐POD‐M possesses similar disinfection treatment and wound skin recovery efficiencies to vancomycin. It is suggested that this inexpensive, durable, and highly reactive oxygen species (ROS) catalytic active V‐POD‐M provides a promising broad‐spectrum therapy for nonantibiotic disinfection.