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Liquid‐Flowing Graphene Chip‐Based High‐Resolution Electron Microscopy
Author(s) -
Koo Kunmo,
Park Jungjae,
Ji Sanghyeon,
Toleukhanova Saltanat,
Yuk Jong Min
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202005468
Subject(s) - graphene , materials science , nanotechnology , resolution (logic) , transmission electron microscopy , biomolecule , microscopy , liquid crystal , optoelectronics , optics , computer science , artificial intelligence , physics
The recent advances in liquid‐phase transmission electron microscopy represent tremendous potential in many different fields and exciting new opportunities. However, achieving both high‐resolution imaging and operando capabilities remain a significant challenge. This work suggests a novel in situ imaging platform of liquid‐flowing graphene chip TEM (LFGC‐TEM) equipped with graphene viewing windows and a liquid exchange system. The LFGCs are robust under high‐pressure gradients and rapid liquid circulation in ranges covering the experimental conditions accessible with conventional thick SiN x chips. LFGC‐TEM provides atomic resolution for colloidal nanoparticles and molecular‐level information limits for unstained wet biomolecules and cells that are comparable to the resolutions achievable with solid‐phase and cryogenic TEM, respectively. This imaging platform can provide an opportunity for live imaging of biological phenomena that is not yet achieved using any current methods.