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Near‐Infrared AIE Dots with Chemiluminescence for Deep‐Tissue Imaging
Author(s) -
Liu Chenchen,
Wang Xiuxia,
Liu Junkai,
Yue Qiang,
Chen Sijie,
Lam Jacky W. Y.,
Luo Liang,
Tang Ben Zhong
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202004685
Subject(s) - near infrared spectroscopy , materials science , fluorescence , triphenylamine , chemiluminescence , in vivo , aggregation induced emission , conjugated system , photochemistry , biophysics , nanotechnology , optoelectronics , chemistry , organic chemistry , optics , polymer , physics , microbiology and biotechnology , composite material , biology
Near‐infrared (NIR) chemiluminescence (CL) emission is highly favorable for deep‐tissue imaging, but chemically conjugated NIR CL emitters with the aggregation‐induced emission (AIE) property for biotechnology are seldom reported. Herein, an AIE‐active NIR CL emitter, TBL, is synthesized by conjugating luminol unit with electron‐accepting benzothiadiazole and an electron‐donating triphenylamine, and subsequently TBL dots are prepared by using F127 as the surfactant. The CL emission of TBL dots can last continuously for over 60 min and can be employed for quantitative (in vitro) and qualitative (in vivo) detection of 1 O 2 . Strikingly, the NIR CL emission can penetrate through tissues with a total thickness of over 3 cm, exhibiting significantly better performance than NIR fluorescence emission and blue CL emission. Moreover, the successful differentiation of tumor and normal tissues by TBL‐based CL imaging in vivo also paves the way for CL‐guided cancer diagnosis and surgery.