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Electromagnetized‐Nanoparticle‐Modulated Neural Plasticity and Recovery of Degenerative Dopaminergic Neurons in the Mid‐Brain
Author(s) -
Zhao Di,
Feng PeiJian,
Liu JiaHao,
Dong Mei,
Shen XiaoQuan,
Chen YingXin,
Shen QunDong
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202003800
Subject(s) - dopaminergic , dopamine , neuroscience , neuroplasticity , tyrosine hydroxylase , synaptic plasticity , neurotransmitter , biological neural network , neural stem cell , materials science , biology , microbiology and biotechnology , central nervous system , stem cell , biochemistry , receptor
The degeneration of dopaminergic neurons is a major contributor to the pathogenesis of mid‐brain disorders. Clinically, cell therapeutic solutions, by increasing the neurotransmitter dopamine levels in the patients, are hindered by low efficiency and/or side effects. Here, a strategy using electromagnetized nanoparticles to modulate neural plasticity and recover degenerative dopamine neurons in vivo is reported. Remarkably, electromagnetic fields generated by the nanoparticles under ultrasound stimulation modulate intracellular calcium signaling to influence synaptic plasticity and control neural behavior. Dopaminergic neuronal functions are reversed by upregulating the expression tyrosine hydroxylase, thus resulting in ameliorating the neural behavioral disorders in zebrafish. This wireless tool can serve as a viable and safe strategy for the regenerative therapy of the neurodegenerative disorders.