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Superamphiphilic TiO 2 Composite Surface for Protein Antifouling
Author(s) -
Li Ning,
Xu Zhe,
Zheng Shuang,
Dai Haoyu,
Wang Li,
Tian Ye,
Dong Zhichao,
Jiang Lei
Publication year - 2021
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202003559
Subject(s) - protein adsorption , biofouling , materials science , adsorption , microfluidics , wetting , fouling , biomolecule , nanotechnology , adhesion , coating , capillary action , composite number , chemical engineering , polymer , composite material , chemistry , organic chemistry , biochemistry , membrane , engineering
Unwanted protein adsorption deteriorates fouling processes and reduces analytical device performance. Wettability plays an important role in protein adsorption by affecting interactions between proteins and surfaces. However, the principles of protein adsorption are not completely understood, and surface coatings that exhibit resistance to protein adsorption and long‐term stability still need to be developed. Here, a nanostructured superamphiphilic TiO 2 composite (TiO 2 /SiO 2 ) coating that can effectively prevent nonspecific protein adsorption on water/solid interfaces is reported. The confined water on the superamphiphilic surface enables a low adhesion force and the formation of an energy barrier that plays a key role in preventing protein adsorption. This adaptive design protects the capillary wall from fouling in a harsh environment during the bioanalysis of capillary electrophoresis and is further extended to applications in multifunctional microfluidics for liquid transportation. This facile approach is not only perfectly applied in channels with complicated configurations but may also offer significant insights into the design of advanced superwetting materials to control biomolecule adhesion in biomedical devices, microfluidics, and biological assays.