Premium
Tocilizumab–Conjugated Polymer Nanoparticles for NIR‐II Photoacoustic‐Imaging‐Guided Therapy of Rheumatoid Arthritis
Author(s) -
Chen Jingqin,
Qi Ji,
Chen Chao,
Chen Jianhai,
Liu Liangjian,
Gao Rongkang,
Zhang Tiantian,
Song Liang,
Ding Dan,
Zhang Peng,
Liu Chengbo
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202003399
Subject(s) - tocilizumab , rheumatoid arthritis , medicine , photoacoustic imaging in biomedicine , photothermal therapy , optical coherence tomography , materials science , radiology , nanotechnology , optics , physics
The progressive debilitating nature of rheumatoid arthritis (RA) combined with its unknown etiology and initial similarity to other inflammatory diseases makes early diagnosis a significant challenge. Early recognition and treatment of RA is essential for achieving effective therapeutic outcome. NIR‐II photoacoustic (PA) molecular imaging (PMI) is emerging as a promising new strategy for effective diagnosis and treatment guidance of RA, owing to its high sensitivity and specificity at large penetration depth. Herein, an antirheumatic targeted drug tocilizumab (TCZ) is conjugated to polymer nanoparticles (PNPs) to develop the first NIR‐II theranostic nanoplatform, named TCZ‐PNPs, for PA‐imaging‐guided therapy of RA. The TCZ‐PNPs are demonstrated to have strong NIR‐II extinction coefficient, high photostability and excellent biocompatibility. NIR‐II PMI results reveal the excellent targeting abilities of TCZ‐PNPs for the effective noninvasive diagnosis of RA joint tissue with a high signal‐to noise ratio (SNR) of 35.8 dB in 3D PA tomography images. Remarkably, one‐month treatment and PA monitoring using TCZ‐PNPs shows RA is significantly suppressed. In addition, the therapeutic evaluation of RA mice by NIR‐II PMI is shown to be consistent with clinical micro‐CT and histological analysis. The TCZ‐PNPs‐assisted NIR‐II PMI provides a new strategy for RA theranostics, therapeutic monitoring and the beyond.