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A Graphdiyne Oxide‐Based Iron Sponge with Photothermally Enhanced Tumor‐Specific Fenton Chemistry
Author(s) -
Min Huan,
Qi Yingqiu,
Zhang Yinlong,
Han Xuexiang,
Cheng Keman,
Liu Ying,
Liu Huibiao,
Hu Jianshe,
Nie Guangjun,
Li Yiye
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.202000038
Subject(s) - photothermal therapy , hydrogen peroxide , radical , fenton reaction , materials science , iron oxide nanoparticles , iron oxide , hydroxyl radical , reactive oxygen species , nanocomposite , photothermal effect , nanoparticle , nanotechnology , combinatorial chemistry , chemistry , organic chemistry , biochemistry , metallurgy
Fenton reaction‐mediated oncotherapy is an emerging strategy which uses iron ions to catalytically convert endogenous hydrogen peroxide into hydroxyl radicals, the most reactive oxygen species found in biology, for efficient cancer therapy. However, Fenton reaction efficiency in tumor tissue is typically limited due to restrictive conditions. One strategy to overcome this obstacle is to increase the temperature specifically at the tumor site. Herein, a tumor‐targeting iron sponge (TTIS) nanocomposite based on graphdiyne oxide, which has a high affinity for iron is described. TTIS can accumulate in tumor tissue by decoration with a tumor‐targeting polymer to enable tumor photoacoustic and magnetic resonance imaging. With its excellent photothermal conversion efficiency (37.5%), TTIS is an efficient photothermal therapy (PTT) agent. Moreover, the heat produced in the process of PTT can accelerate the release of iron ions from TTIS and simultaneously enhance the efficiency of the Fenton reaction, thus achieving a combined PTT and Fenton reaction‐mediated cancer therapy. This work introduces a graphdiyne oxide‐based iron sponge that exerts an enhanced antitumor effect through PTT and Fenton chemistry.