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Neural Regeneration: Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration (Adv. Mater. 33/2019)
Author(s) -
Xu Duo,
Wu Di,
Qin Meng,
Nih Lina R.,
Liu Chaoyong,
Cao Zheng,
Ren Jie,
Chen Xiangjun,
He Zhanlong,
Yu Wenhai,
Guan Jiaoqiong,
Duan Suqin,
Liu Fang,
Liu Xiangsheng,
Li Jesse,
Harley Dushawn,
Xu Bin,
Hou Lihua,
Chen Irvin S. Y.,
Wen Jing,
Chen Wei,
Pourtaheri Sina,
Lu Yunfeng
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201970233
Subject(s) - regeneration (biology) , central nervous system , neural tissue engineering , spinal cord , nervous system , neuroscience , neurotrophin , nerve growth factor , regenerative medicine , neurotrophin 3 , materials science , delivery system , biology , biomedical engineering , neurotrophic factors , medicine , brain derived neurotrophic factor , microbiology and biotechnology , stem cell , receptor
Neurotrophins are promising candidates for central nervous system (CNS) diseases and injuries, while their inability to enter the CNS remains a bottleneck for therapeutic purposes. In article number 1900727, Jing Wen, Wei Chen, Sina Pourtaheri, Yunfeng Lu, and co‐workers report a nanocapsule‐based delivery strategy, which enables the efficient entry of nerve growth factors (NGFs) to the CNS. In mice with spinal cord injuries, the effective delivery of NGF promotes neural regeneration, tissue remodeling, and functional recovery.