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Photothermal Therapy: Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells (Adv. Mater. 23/2019)
Author(s) -
Chen Qian,
Hu Quanyin,
Dukhovlinova Elena,
Chen Guojun,
Ahn Sarah,
Wang Chao,
Ogunnaike Edikan A.,
Ligler Frances S.,
Dotti Gianpietro,
Gu Zhen
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201970166
Subject(s) - photothermal therapy , cancer research , hyperthermia , immune system , materials science , infiltration (hvac) , melanoma , medicine , immunology , nanotechnology , composite material
CAR‐T lymphocytes show modest therapeutic efficacy in solid tumors. Mild hyperthermia of the tumor reduces its compact structure and interstitial fluid pressure (IFP), increases blood perfusion, releases antigens, and promotes the recruitment of endogenous immune cells. In article number 1900192 , Gianpietro Dotti, Zhen Gu, and co‐workers find that CSPG 4 ‐specific CAR‐T cells infused in NSG mice engrafted with the human melanoma WM115 cell line had superior antitumor activity after photothermal ablation of the tumor. These findings suggest that photothermal therapy facilitates the accumulation and effector function of CAR‐T cells within tumors.