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Biointerfaces: Porous Silicon Nanoneedles Modulate Endocytosis to Deliver Biological Payloads (Adv. Mater. 12/2019)
Author(s) -
Gopal Sahana,
Chiappini Ciro,
Penders Jelle,
Leonardo Vincent,
Seong Hyejeong,
Rothery Stephen,
Korchev Yuri,
Shevchuk Andrew,
Stevens Molly M.
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201970086
Subject(s) - endocytic cycle , endocytosis , materials science , nanotechnology , mesenchymal stem cell , microbiology and biotechnology , nanoneedle , porous silicon , intracellular , silicon , biophysics , cell , biology , nanostructure , biochemistry , optoelectronics
In article number 1806788 , Ciro Chiappini, Andrew Shevchuk, Molly M. Stevens, and co‐workers show that porous silicon nanoneedles stimulate endocytic activity in mesenchymal stem cells. Endocytic pits localize around the nanoneedles leading to increased uptake of pathway‐specific payloads and their endolysosomal trafficking, yet nucleic acids delivered from nanoneedles retain their biological activity, suggesting the overlap of concurrent delivery mechanisms. These findings significantly advance the current understanding of the mechanisms of intracellular delivery by nanoinjection.