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Human In Vivo Corona: The Human In Vivo Biomolecule Corona onto PEGylated Liposomes: A Proof‐of‐Concept Clinical Study (Adv. Mater. 4/2019)
Author(s) -
Hadjidemetriou Marilena,
McAdam Sarah,
Garner Grace,
Thackeray Chelsey,
Knight David,
Smith Duncan,
AlAhmady Zahraa,
Mazza Mariarosa,
Rogan Jane,
Clamp Andrew,
Kostarelos Kostas
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201970027
Subject(s) - biomolecule , in vivo , materials science , liposome , corona (planetary geology) , nanotechnology , nanomedicine , lipid bilayer , proteome , biophysics , vesicle , nanoparticle , membrane , chemistry , biochemistry , biology , microbiology and biotechnology , astrobiology , venus
Experimental evidence that a biomolecule corona self‐assembles around clinically used nanoparticles in humans while in their blood circulation is presented by Kostas Kostarelos and co‐workers in article number 1803335 . The successful recovery and purification of corona‐coated lipid bilayer vesicles (liposomes) from the blood circulation of ovarian carcinoma patients allows the proteomic analysis of the human in vivo protein corona. This work provides a technology springboard to allow clinical exploitation of protein‐corona fingerprinting as a novel tool to comprehensively analyze the blood circulation proteome.