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Bioactive Pore‐Forming Bone Adhesives Facilitating Cell Ingrowth for Fracture Healing
Author(s) -
Xu Liju,
Gao Shan,
Zhou Rubing,
Zhou Fang,
Qiao Yan,
Qiu Dong
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201907491
Subject(s) - materials science , adhesive , bone healing , biomedical engineering , scaffold , stromal cell , bioactive glass , mesenchymal stem cell , macropore , nanotechnology , composite material , layer (electronics) , anatomy , chemistry , medicine , pathology , mesoporous material , biochemistry , catalysis
The effectiveness of commercial bone adhesives is known to be hampered by the weak efficacy of cell ingrowth. The strategy of macropore‐forming, especially bioactive macropores, holds considerable promise to circumvent this problem, thereby promoting fracture healing. Herein, a class of bioactive glass‐involved macropore‐embedded bone adhesives is developed, which is capable of facilitating the migration of bone‐derived mesenchymal stromal cells into the adhesive layer and differentiation into osteocytes. The integration of bioactive glass‐particle‐encapsulated porogens in the bone adhesives is key to this approach. A robust instant bonding on the bone adhesive and a high efficiency of bone regeneration on a mouse skull are observed, both of which are vital for clinical applications and personalized surgical procedures. This work represents a general strategy to design biomaterials with high cell‐ingrowth efficacy.