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Fabrication and Mechanical Properties of Engineered Protein‐Based Adhesives and Fibers
Author(s) -
Sun Jing,
Su Juanjuan,
Ma Chao,
Göstl Robert,
Herrmann Andreas,
Liu Kai,
Zhang Hongjie
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201906360
Subject(s) - spider silk , materials science , adhesive , nanotechnology , bioadhesive , adhesion , self healing hydrogels , tissue engineering , drug delivery , biofabrication , elastin , fabrication , surface modification , silk , biomedical engineering , composite material , chemistry , biology , polymer chemistry , medicine , alternative medicine , layer (electronics) , pathology , genetics
Protein‐based structural biomaterials are of great interest for various applications because the sequence flexibility within the proteins may result in their improved mechanical and structural integrity and tunability. As the two representative examples, protein‐based adhesives and fibers have attracted tremendous attention. The typical protein adhesives, which are secreted by mussels, sandcastle worms, barnacles, and caddisfly larvae, exhibit robust underwater adhesion performance. In order to mimic the adhesion performance of these marine organisms, two main biological adhesives are presented, including genetically engineered protein‐based adhesives and biomimetic chemically synthetized adhesives. Moreover, various protein‐based fibers inspired by spider and silkworm proteins, collagen, elastin, and resilin are studied extensively. The achievements in synthesis and fabrication of structural biomaterials by DNA recombinant technology and chemical regeneration certainly will accelerate the explorations and applications of protein‐based adhesives and fibers in wound healing, tissue regeneration, drug delivery, biosensors, and other high‐tech applications. However, the mechanical properties of the biological structural materials still do not match those of natural systems. More efforts need to be devoted to the study of the interplay of the protein structure, cohesion and adhesion effects, fiber processing, and mechanical performance.