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Plasmonic Pt Superstructures with Boosted Near‐Infrared Absorption and Photothermal Conversion Efficiency in the Second Biowindow for Cancer Therapy
Author(s) -
Wang Qishun,
Wang Huan,
Yang Yang,
Jin Longhai,
Liu Yang,
Wang Ying,
Yan Xiangyu,
Xu Jing,
Gao Ruoqian,
Lei Pengpeng,
Zhu Junjie,
Wang Yinghui,
Song Shuyan,
Zhang Hongjie
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201904836
Subject(s) - photothermal therapy , materials science , plasmon , photothermal effect , surface plasmon resonance , optoelectronics , nanotechnology , nanoparticle
Photothermal therapy triggered by near‐infrared light in the second biowindow (NIR‐II) has attracted extensive interest owing to its deeper penetration depth of biological tissue, lower photon scattering, and higher maximum permissible exposure. In spite of noble metals showing great potential as the photothermal agents due to the tunable localized surface plasmon resonance, the biological applications of platinum are rarely explored. Herein, a monocomponent hollow Pt nanoframe (“Pt Spirals”), whose superstructure is assembled with three levels (3D frame, 2D layered shells, and 1D nanowires), is reported. Pt Spirals exhibit outstanding photothermal conversion efficiency (52.5%) and molar extinction coefficients (228.7 m 2 mol −1 ) in NIR‐II, which are much higher than those of solid Pt cubes. Simulations indicate that the unique superstructure can be a significant cause for improving both adsorption and the photothermal effect simultaneously in NIR‐II. The excellent photothermal effect is achieved and subsequently verified in in vitro and in vivo experiments, along with superb heat‐resistance properties, excellent photostability, and a prominent effect on computed tomography (CT) imaging, demonstrating that Pt Spirals are promising as effective theranostic platforms for CT imaging‐guided photothermal therapy.