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Remote Magnetic Nanoparticle Manipulation Enables the Dynamic Patterning of Cardiac Tissues
Author(s) -
ZwiDantsis Limor,
Wang Brian,
Marijon Camille,
Zonetti Simone,
Ferrini Arianna,
Massi Lucia,
Stuckey Daniel J.,
Terracciano Cesare M.,
Stevens Molly M.
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201904598
Subject(s) - materials science , regenerative medicine , nanotechnology , self healing hydrogels , magnetic nanoparticles , tissue engineering , iron oxide nanoparticles , nanoparticle , biomedicine , biomedical engineering , computer science , cell , bioinformatics , engineering , chemistry , biology , biochemistry , polymer chemistry
The ability to manipulate cellular organization within soft materials has important potential in biomedicine and regenerative medicine; however, it often requires complex fabrication procedures. Here, a simple, cost‐effective, and one‐step approach that enables the control of cell orientation within 3D collagen hydrogels is developed to dynamically create various tailored microstructures of cardiac tissues. This is achieved by incorporating iron oxide nanoparticles into human cardiomyocytes and applying a short‐term external magnetic field to orient the cells along the applied field to impart different shapes without any mechanical support. The patterned constructs are viable and functional, can be detected by T 2 *‐weighted magnetic resonance imaging, and induce no alteration to normal cardiac function after grafting onto rat hearts. This strategy paves the way to creating customized, macroscale, 3D tissue constructs with various cell‐types for therapeutic and bioengineering applications, as well as providing powerful models for investigating tissue behavior.