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Biodegradable Nanoprodrugs: “Delivering” ROS to Cancer Cells for Molecular Dynamic Therapy
Author(s) -
Tang Zhongmin,
Liu Yanyan,
Ni Dalong,
Zhou Jiajia,
Zhang Meng,
Zhao Peiran,
Lv Bin,
Wang Han,
Jin Dayong,
Bu Wenbo
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201904011
Subject(s) - materials science , cancer therapy , nanotechnology , cancer , cancer cell , cancer research , medicine
Biodegradable nanoprodrugs, inheriting the antitumor effects of chemotherapy drugs and overcoming the inevitable drawback of side effects on normal tissues, hold promise as next‐generation cancer therapy candidates. Biodegradable nanoprodrugs of transferrin‐modified MgO 2 nanosheets are developed to selectively deliver reactive oxygen species to cancer cells for molecular dynamic therapy strategy. The nanosheets favor the acidic and low catalase activity tumor microenvironment to react with proton and release nontoxic Mg 2+ . This reaction simultaneously produces abundant H 2 O 2 to induce cell death and damage the structure of transferrin to release Fe 3+ , which will react with H 2 O 2 to produce highly toxic ·OH to kill tumor cells.