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X‐ray‐Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery
Author(s) -
Deng Hongzhang,
Lin Lisen,
Wang Sheng,
Yu Guocan,
Zhou Zijian,
Liu Yijing,
Niu Gang,
Song Jibin,
Chen Xiaoyuan
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201903443
Subject(s) - nanocapsules , nucleobase , bilayer , drug delivery , materials science , pairing , azobenzene , nanotechnology , nanocarriers , nanoparticle , biophysics , drug , controlled release , membrane , chemistry , dna , polymer , pharmacology , biochemistry , superconductivity , physics , quantum mechanics , composite material , biology , medicine
The targeted and sustained drug release from stimuli‐responsive nanodelivery systems is limited by the irreversible and uncontrolled disruption of the currently used nanostructures. Bionic nanocapsules are designed by cross‐linking polythymine and photoisomerized polyazobenzene (PETAzo) with adenine‐modified ZnS (ZnS‐A) nanoparticles (NPs) via nucleobase pairing. The ZnS‐A NPs convert X‐rays into UV radiation that isomerizes the azobenzene groups, which allows controlled diffusion of the active payloads across the bilayer membranes. In addition, the nucleobase pairing interactions between PETAzo and ZnS‐A prevent drug leakage during their in vivo circulation, which not only enhances tumor accumulation but also maintains stability. These nanocapsules with tunable permeability show prolonged retention, remotely controlled drug release, enhanced targeted accumulation, and effective antitumor effects, indicating their potential as an anticancer drug delivery system.