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Surfactant‐Stripped Micelles for NIR‐II Photoacoustic Imaging through 12 cm of Breast Tissue and Whole Human Breasts
Author(s) -
Chitgupi Upendra,
Nyayapathi Nikhila,
Kim Jeesu,
Wang Depeng,
Sun Boyang,
Li Changning,
Carter Kevin,
Huang WeiChiao,
Kim Chulhong,
Xia Jun,
Lovell Jonathan F.
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201902279
Subject(s) - materials science , cyanine , absorption (acoustics) , micelle , near infrared spectroscopy , pulmonary surfactant , photoacoustic imaging in biomedicine , biomedical engineering , aqueous solution , fluorescence , chemistry , optics , medicine , composite material , biochemistry , physics
Surfactant‐stripped micelles are formed from a commercially available cyanine fluoroalkylphosphate (CyFaP) salt dye and used for high contrast photoacoustic imaging (PAI) in the second near‐infrared window (NIR‐II). The co‐loading of Coenzyme Q10 into surfactant‐stripped CyFaP (ss‐CyFaP) micelles improves yield, storage stability, and results in a peak absorption wavelength in the NIR‐II window close to the 1064 nm output of Nd‐YAG lasers used for PAI. Aqueous ss‐CyFaP dispersions exhibit intense NIR‐II optical absorption, calculated to be greater than 500 at 1064 nm. ss‐CyFaP is detected through 12 cm of chicken breast tissue with PAI. In preclinical animal models, ss‐CyFaP is visualized in draining lymph nodes of rats through 3.1 cm of overlaid chicken breast tissue. Following intravenous administration, ss‐CyFaP accumulates in neoplastic tissues of mice and rats bearing orthotopic mammary tumors without observation of acute toxic side effects. ss‐CyFaP is imaged through whole compressed human breasts in three female volunteers at depths of 2.6–5.1 cm. Taken together, these data show that ss‐CyFaP is an accessible contrast agent for deep tissue PAI in the NIR‐II window.