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Epitope Imprinting Technology: Progress, Applications, and Perspectives toward Artificial Antibodies
Author(s) -
Yang Kaiguang,
Li Senwu,
Liu Lukuan,
Chen Yuwan,
Zhou Wen,
Pei Jiaqi,
Liang Zhen,
Zhang Lihua,
Zhang Yukui
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201902048
Subject(s) - epitope , imprinting (psychology) , molecular imprinting , bioanalysis , materials science , computational biology , nanotechnology , biology , antibody , immunology , genetics , biochemistry , selectivity , gene , catalysis
Epitope imprinting is a promising tool to generate antibody‐like specific recognition sites. Recently, because of the ease of obtaining templates, the flexibility in selecting monomers, their resistance to harsh environments, and the high specificity toward targets, epitope‐imprinted materials have attracted much attention in various fields, such as bioanalysis, clinical therapy, and pharmacy. Here, the discussion is focused on the current representative epitope imprinting technologies, including epitope bulk imprinting and epitope surface imprinting. Moreover, the application of epitope‐imprinted materials to the recognition of peptides, proteins, and cells is reviewed. Finally, the remaining challenges arising from the intrinsic properties of epitope imprinting are discussed, and future development in the field is prospected.