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A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy
Author(s) -
Wang Dongdong,
Wu Huihui,
Lim Wei Qi,
Phua Soo Zeng Fiona,
Xu Pengping,
Chen Qianwang,
Guo Zhen,
Zhao Yanli
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201901893
Subject(s) - mesoporous material , photodynamic therapy , materials science , singlet oxygen , photosensitizer , mesoporous silica , mesoporous organosilica , metal organic framework , ethylene glycol , in vivo , biocompatibility , oxygen , nanotechnology , catalysis , photochemistry , chemistry , organic chemistry , adsorption , microbiology and biotechnology , metallurgy , biology
Abstract Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as the local oxygen concentration plays an important role in the generation of cytotoxic singlet oxygen ( 1 O 2 ). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal–organic frameworks (MOFs) is presented for in situ generation of endogenous O 2 to enhance the PDT efficacy under bioimaging guidance. The mesoporous NE is constructed by first coating a manganese‐based MOFs with mesoporous silica, followed by a facile annealing process under the ambient atmosphere. After removing the mesoporous silica shell and post‐modifying with polydopamine and poly(ethylene glycol) for improving the biocompatibility, the obtained mesoporous NE is loaded with chlorin e6 (Ce6), a commonly used photosensitizer in PDT, with a high loading capacity. Upon the O 2 generation through the catalytic reaction between the catalytic amount NE and the endogenous H 2 O 2 , the hypoxic tumor microenvironment is relieved. Thus, Ce6‐loaded NE serves as a H 2 O 2 ‐activated oxygen supplier to increase the local O 2 concentration for significantly enhanced antitumor PDT efficacy in vitro and in vivo. In addition, the NE also shows T 2 ‐weighted magnetic resonance imaging ability for its in vivo tracking. This work presents an interesting biomedical use of MOF‐derived mesoporous NE as a multifunctional theranostic agent in cancer therapy.