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Mitigation of Amyloidosis with Nanomaterials
Author(s) -
Ke Pu Chun,
Pilkington Emily H.,
Sun Yunxiang,
Javed Ibrahim,
Kakinen Aleksandr,
Peng Guotao,
Ding Feng,
Davis Thomas P.
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201901690
Subject(s) - nanomaterials , nanotechnology , amyloidosis , materials science , amyloid (mycology) , amyloid fibril , biophysics , chemistry , biology , medicine , amyloid β , inorganic chemistry , disease , pathology
Abstract Amyloidosis is a biophysical phenomenon of protein aggregation with biological and pathogenic implications. Among the various strategies developed to date, nanomaterials and multifunctional nanocomposites possessing certain structural and physicochemical traits are promising candidates for mitigating amyloidosis in vitro and in vivo. The mechanisms underpinning protein aggregation and toxicity are introduced, and opportunities in materials science to drive this interdisciplinary field forward are highlighted. Advancement of this emerging frontier hinges on exploitation of protein self‐assembly and interactions of amyloid proteins with nanoparticles, intracellular and extracellular proteins, chaperones, membranes, organelles, and biometals.