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Artificial Super Neutrophils for Inflammation Targeting and HClO Generation against Tumors and Infections
Author(s) -
Zhang Chi,
Zhang Lu,
Wu Wei,
Gao Fan,
Li RunQing,
Song Wen,
Zhuang ZeNan,
Liu ChuanJun,
Zhang XianZheng
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201901179
Subject(s) - hypochlorous acid , inflammation , innate immune system , in vivo , immune system , neutrophil extracellular traps , materials science , cancer research , nadph oxidase , glucose oxidase , effector , nanotechnology , biology , immunology , reactive oxygen species , biochemistry , microbiology and biotechnology , biosensor
Neutrophils are powerful effector leukocytes that play an important role in innate immune systems for opposing tumor progression and ameliorating pathogen infections. Inspired by their distinct functions against tumors and infections, the artificial “super neutrophils” are proposed with excellent inflammation targeting and hypochlorous acid (HClO) generation characteristics for targeting and eliminating malignant tumor cells and pathogens. The “super neutrophils” are fabricated by embedding glucose oxidase (GOx) and chloroperoxidase (CPO) into zeolitic imidazolate framework‐8 (ZIF‐8) for HClO generation via enzymatic cascades, and then encapsulating them with the neutrophil membrane (NM) for inflammation targeting. In vitro and in vivo results indicate that these artificial “super neutrophils” can generate seven times higher reactive HClO than the natural neutrophils for eradicating tumors and infections. The “super neutrophils” demonstrated here with easy fabrication and good neutrophil‐mimicking property exhibit great potential for biomedical applications.