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pH‐Regulated Heterostructure Porous Particles Enable Similarly Sized Protein Separation
Author(s) -
Song Yongyang,
Fan JunBing,
Li Xiuling,
Liang Xinmiao,
Wang Shutao
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201900391
Subject(s) - materials science , adsorption , biomolecule , polymerization , porosity , chemical engineering , emulsion , protein adsorption , homogeneous , nanotechnology , polymer , chemistry , organic chemistry , composite material , physics , engineering , thermodynamics
Porous particles are frequently used for various healthcare applications that involve protein separation processes. However, conventional porous particles, either homogeneous particles or those subjected to surface modification with a layer of specific molecules, often encounter bottlenecks in separating proteins with similar size. Here, it is reported that heterostructure‐enabled separation particles (HESP), synthesized by a double emulsion interfacial polymerization process, can effectively and rapidly separate similarly sized proteins. Double emulsion interfacial polymerization endows the HESP with a nanoscale carboxylic layer outside the particles and inside the pores, allowing pH‐regulated selective adsorption of proteins. Thus, by optimizing the environmental pH, proteins with similar size can be effectively and rapidly separated. These HESP are expected to show potential in widespread applications ranging from biomolecule adsorption, encapsulation, and separation to controlled release and other biomedical fields.