Premium
Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells
Author(s) -
Chen Qian,
Hu Quanyin,
Dukhovlinova Elena,
Chen Guojun,
Ahn Sarah,
Wang Chao,
Ogunnaike Edikan A.,
Ligler Frances S.,
Dotti Gianpietro,
Gu Zhen
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201900192
Subject(s) - cancer research , chimeric antigen receptor , tumor microenvironment , materials science , immune system , photothermal therapy , immunotherapy , immunology , medicine , tumor cells , nanotechnology
Chimeric antigen receptor (CAR)‐redirected T lymphocytes (CAR T cells) show modest therapeutic efficacy in solid tumors. The desmoplastic structure of the tumor and the immunosuppressive tumor microenvironment usually account for the reduced efficacy of CAR T cells in solid tumors. Mild hyperthermia of the tumor reduces its compact structure and interstitial fluid pressure, increases blood perfusion, releases antigens, and promotes the recruitment of endogenous immune cells. Therefore, the combination of mild hyperthermia with the adoptive transfer of CAR T cells can potentially increase the therapeutic index of these cells in solid tumors. It is found that the chondroitin sulfate proteoglycan‐4 (CSPG4)‐specific CAR T cells infused in Nod scid gamma mice engrafted with the human melanoma WM115 cell line have superior antitumor activity after photothermal ablation of the tumor. The findings suggest that photothermal therapy facilitates the accumulation and effector function of CAR T cells within solid tumors.