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Regenerative Medicine: A Programmed Anti‐Inflammatory Nanoscaffold (PAIN) as a 3D Tool to Understand the Brain Injury Response (Adv. Mater. 50/2018)
Author(s) -
Maclean Francesca L.,
Ims Georgina M.,
Horne Malcolm K.,
Williams Richard J.,
Nisbet David R.
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201870381
Subject(s) - materials science , regenerative medicine , nanobiotechnology , nanotechnology , inflammation , regeneration (biology) , inflammatory response , scaffold , neuroscience , microbiology and biotechnology , biomedical engineering , medicine , stem cell , biology , nanoparticle , immunology
The inflammatory environment post injury is a key mechanism in guiding regeneration. However, reproducing this process is a significant biological challenge. In article number 1805209 , Richard J. Williams, David R. Nisbet, and co‐workers demonstrate a nanostructured scaffold that can sustain astrocytes in long‐term culture; then, using nanobiotechnology, they switch inflammation on or off in a programmed fashion to simulate the response to healthy or damaged tissue.