Regenerative Medicine: A Programmed Anti‐Inflammatory Nanoscaffold (PAIN) as a 3D Tool to Understand the Brain Injury Response (Adv. Mater. 50/2018) | Zendy

Maclean Francesca L. | Zendy; Ims Georgina M. | Zendy; Horne Malcolm K. | Zendy; Williams Richard J. | Zendy; Nisbet David R. | Zendy

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Regenerative Medicine: A Programmed Anti‐Inflammatory Nanoscaffold (PAIN) as a 3D Tool to Understand the Brain Injury Response (Adv. Mater. 50/2018)

Author(s) -

Maclean Francesca L.,

Ims Georgina M.,

Horne Malcolm K.,

Williams Richard J.,

Nisbet David R.

Publication year - 2018

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201870381

Subject(s) - materials science , regenerative medicine , nanobiotechnology , nanotechnology , inflammation , regeneration (biology) , inflammatory response , scaffold , neuroscience , microbiology and biotechnology , biomedical engineering , medicine , stem cell , biology , nanoparticle , immunology

The inflammatory environment post injury is a key mechanism in guiding regeneration. However, reproducing this process is a significant biological challenge. In article number 1805209 , Richard J. Williams, David R. Nisbet, and co‐workers demonstrate a nanostructured scaffold that can sustain astrocytes in long‐term culture; then, using nanobiotechnology, they switch inflammation on or off in a programmed fashion to simulate the response to healthy or damaged tissue.

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