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Photodynamic Therapy: Responsive Assembly of Upconversion Nanoparticles for pH‐Activated and Near‐Infrared‐Triggered Photodynamic Therapy of Deep Tumors (Adv. Mater. 35/2018)
Author(s) -
Li Fangyuan,
Du Yang,
Liu Jianan,
Sun Heng,
Wang Jin,
Li Ruiqing,
Kim Dokyoon,
Hyeon Taeghwan,
Ling Daishun
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201870264
Subject(s) - photodynamic therapy , photosensitizer , photon upconversion , nanoparticle , materials science , photochemistry , biophysics , nanotechnology , optoelectronics , chemistry , doping , organic chemistry , biology
Stimuli‐responsive smart photodynamic agents are highly desirable for photodynamic therapy. In article number 1802808 , Daishun Ling and co‐workers report tumor‐pH‐sensitive photodynamic nanoagents composed of self‐assembled photosensitizer‐grafted pH‐responsive polymeric ligands and upconversion nanoparticles (UCNPs). The nanoagents are self‐quenched in physiological pH conditions. In a mild acidic tumor environment, they can be efficiently internalized by tumor cells due to surface charge reversal, and further become disassembled into well‐dispersed nanoparticles in intracellular tumor pH value, resulting in the UCNP‐mediated activation of photosensitizers by near‐infrared light.