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Nanomedicine: Silver Atomic Quantum Clusters of Three Atoms for Cancer Therapy: Targeting Chromatin Compaction to Increase the Therapeutic Index of Chemotherapy (Adv. Mater. 33/2018)
Author(s) -
Porto Vanesa,
Borrajo Erea,
Buceta David,
Carneiro Carmen,
Huseyinova Shahana,
Domínguez Blanca,
Borgman Kyra J. E.,
Lakadamyali Melike,
GarciaParajo Maria F.,
Neissa José,
GarcíaCaballero Tomás,
Barone Giampaolo,
Blanco M. Carmen,
Busto Natalia,
García Begoña,
Leal José Maria,
Blanco José,
Rivas José,
LópezQuintela M. Arturo,
Domínguez Fernando
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201870249
Subject(s) - chromatin , nanomedicine , therapeutic index , materials science , compaction , chemotherapy , cancer , dna , cancer research , nanotechnology , biophysics , drug , medicine , pharmacology , biology , biochemistry , nanoparticle , composite material
Evidence of the significance of targeting chromatin compaction to increase the therapeutic index of chemotherapy is provided by Arturo López‐Quintela, Fernando Domínguez, and co‐workers in article number 1801317 . Co‐administration of silver quantum clusters of three atoms, which increases chromatin accessibility, raises the efficacy of DNA‐binding drugs and the standard of care‐treatment of most human tumors.