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Nanoprobes: “Dual Lock‐and‐Key”‐Controlled Nanoprobes for Ultrahigh Specific Fluorescence Imaging in the Second Near‐Infrared Window (Adv. Mater. 31/2018)
Author(s) -
Tang Yufu,
Li Yuanyuan,
Hu Xiaoming,
Zhao Hui,
Ji Yu,
Chen Liang,
Hu Wenbo,
Zhang Wansu,
Li Xiang,
Lu Xiaomei,
Huang Wei,
Fan Quli
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201870226
Subject(s) - nanoprobe , materials science , fluorescence , near infrared spectroscopy , signal (programming language) , nanotechnology , optoelectronics , fluorescence lifetime imaging microscopy , lock (firearm) , dual (grammatical number) , nanoparticle , optics , computer science , programming language , mechanical engineering , art , physics , literature , engineering
Effectively suppressing the interference signal of the background is still an enormous challenge for obtaining target‐specific near‐infrared II (NIR‐II, 1.0–1.7 μm) fluorescence imaging in the complex and dynamic physiological environment. In article number 1801140 , Quli Fan and co‐workers report a dual‐pathological‐parameter cooperatively activatable NIR‐II fluorescent nanoprobe using a “dual lock‐and‐key” strategy. This “dual lock‐and‐key”‐controlled nanoprobe effectively reduces nonspecific activation, thus significantly suppressing the background signal, causing ultrahigh specific tumor imaging in vivo.