Premium
Cancer Therapy: Programmed Nanoparticle‐Loaded Nanoparticles for Deep‐Penetrating 3D Cancer Therapy (Adv. Mater. 29/2018)
Author(s) -
Kim Jinhwan,
Jo Changshin,
Lim WonGwang,
Jung Sungjin,
Lee Yeong Mi,
Lim Jun,
Lee Haeshin,
Lee Jinwoo,
Kim Won Jong
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201870213
Subject(s) - nanoparticle , materials science , colloidal gold , cancer , nanotechnology , cancer therapy , intracellular , penetration (warfare) , biophysics , medicine , chemistry , biology , biochemistry , operations research , engineering
In article number 1707557 , Jinwoo Lee, Won Jong Kim, and co‐workers demonstrate nanoparticle‐loaded nanoparticles comprising large‐pored silica nanoparticles and gold nanoparticles operated by functional DNA. Depending on the pH gradient in the cancer microenvironment, an elaborately programmed DNA transition induces dynamic behavior of the nanoparticle‐loaded nanoparticle with three stages: preferential accumulation in cancerous region, deep penetration into the 3D cancer tissue, and intracellular specific anticancer drug release.