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Protein Delivery: Bioinspired Diselenide‐Bridged Mesoporous Silica Nanoparticles for Dual‐Responsive Protein Delivery (Adv. Mater. 29/2018)
Author(s) -
Shao Dan,
Li Mingqiang,
Wang Zheng,
Zheng Xiao,
Lao YehHsing,
Chang Zhimin,
Zhang Fan,
Lu Mengmeng,
Yue Juan,
Hu Hanze,
Yan Huize,
Chen Li,
Dong Wenfei,
Leong Kam W.
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201870209
Subject(s) - diselenide , materials science , mesoporous silica , nanoparticle , nanotechnology , mesoporous material , cancer cell , biophysics , selenium , cancer , biochemistry , chemistry , medicine , metallurgy , biology , catalysis
In article number 1801198 , Wen‐fei Dong, Kam W. Leong, and co‐workers report the development of an efficient protein‐delivery system comprising new biodegradable diselenide‐bridged mesoporous silica nanoparticles (MSNs) cloaked with cancer‐cell‐derived membrane fragments. The MSNs show oxidative and redox dual‐responsive matrix‐degradation behavior for controlled release of RNase A. They also exhibit prolonged blood circulation, favorable tumor accumulation, and low toxicity.