Premium
Antibacterial Therapy: Metal–Organic‐Framework‐Assisted In Vivo Bacterial Metabolic Labeling and Precise Antibacterial Therapy (Adv. Mater. 18/2018)
Author(s) -
Mao Duo,
Hu Fang,
Ji Shenglu,
Wu Wenbo,
Ding Dan,
Kong Deling,
Liu Bin
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201870124
Subject(s) - bioorthogonal chemistry , in vivo , photodynamic therapy , photosensitizer , materials science , antibiotics , antibacterial activity , nanotechnology , bacteria , microbiology and biotechnology , chemistry , biology , organic chemistry , click chemistry , polymer chemistry , genetics
In article number 1706831 , Deling Kong, Bin Liu, and co‐workers report a new in vivo antibacterial strategy. With the help of a metal–organic framework, a functionalized amino acid, and photosensitizer nanoparticles with aggregation‐induced emission, bacteria hidden in the body can be specifically detected and killed via bioorthogonal reaction, followed by imaging‐guided photodynamic therapy. This in vivo metabolic labeling method may emerge as a promising alternative to antibiotics in antibacterial therapy.