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Protein Encapsulation: Zwitterionic Nanocages Overcome the Efficacy Loss of Biologic Drugs (Adv. Mater. 14/2018)
Author(s) -
Li Bowen,
Yuan Zhefan,
Zhang Peng,
Sinclair Andrew,
Jain Priyesh,
Wu Kan,
Tsao Caroline,
Xie Jingyi,
Hung HsiangChieh,
Lin Xiaojie,
Bai Tao,
Jiang Shaoyi
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201870101
Subject(s) - nanocages , materials science , encapsulation (networking) , immune system , nanotechnology , medicine , immunology , chemistry , biochemistry , computer science , computer network , catalysis
The induction of an undesirable immune response is a common problem encountered by biologic therapeutics, which can lead to poor clinical outcomes and life‐threatening adverse reactions. The zwitterionic nanocages for protein encapsulation developed by Shaoyi Jiang and co‐workers in article number 1705728 completely prevent the humoral immune response from either protein or polymer and overcome the efficacy loss encountered by current polymer‐conjugated biologics.