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Neuroprotection: Biodegradable Spheres Protect Traumatically Injured Spinal Cord by Alleviating the Glutamate‐Induced Excitotoxicity (Adv. Mater. 14/2018)
Author(s) -
Liu Dongfei,
Chen Jian,
Jiang Tao,
Li Wei,
Huang Yao,
Lu Xiyi,
Liu Zehua,
Zhang Weixia,
Zhou Zheng,
Ding Qirui,
Santos Hélder A.,
Yin Guoyong,
Fan Jin
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201870095
Subject(s) - excitotoxicity , neuroprotection , spinal cord injury , spinal cord , materials science , glutamate receptor , microsphere , cerebrospinal fluid , pharmacology , medicine , chemical engineering , receptor , psychiatry , engineering
New treatment strategies for spinal‐cord injury are being actively pursued. In article number 1706032 , Hélder A. Santos, Guoyong Yin, Jin Fan, and co‐workers show that intrathecally injected biodegradable polymeric microspheres, acetalated dextran, can protect traumatically injured spinal cord. The neuroprotective feature of acetalated dextran microspheres is achieved by sequestering the excessive glutamate and calcium ions in cerebrospinal fluid, and consequently attenuating the glutamateinduced excitotoxicity.