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Drug Delivery: Dimeric Drug Polymeric Micelles with Acid‐Active Tumor Targeting and FRET‐Traceable Drug Release (Adv. Mater. 3/2018)
Author(s) -
Guo Xing,
Wang Lin,
Duval Kayla,
Fan Jing,
Zhou Shaobing,
Chen Zi
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201870020
Subject(s) - förster resonance energy transfer , drug , internalization , cationic polymerization , drug delivery , biophysics , materials science , micelle , targeted drug delivery , intracellular , nanotechnology , combinatorial chemistry , fluorescence , chemistry , biochemistry , pharmacology , organic chemistry , biology , polymer chemistry , cell , physics , quantum mechanics , aqueous solution
In article number 1705436 , Shaobing Zhou, Zi Chen, and co‐workers develop an acid‐active tumor‐targeting nanoplatform with self‐reported drug‐release capability. This platform has unique features, such as a long blood circulation through shielding of the cationic charges of trans‐activating transcriptional activator (TAT), an enhanced cellular internalization by regenerating the original TAT in acidic tumor tissue, and a self‐reported drug release via the Förster resonance energy transfer (FRET) signal triggered by the intracellular reductant.