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A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System
Author(s) -
Wu Di,
Qin Meng,
Xu Duo,
Wang Lan,
Liu Chaoyong,
Ren Jie,
Zhou George,
Chen Chen,
Yang Fengmei,
Li Yanyan,
Zhao Yuan,
Huang Ruyi,
Pourtaheri Sina,
Kang Chunsheng,
Kamata Masakazu,
Chen Irvin S. Y.,
He Zhanlong,
Wen Jing,
Chen Wei,
Lu Yunfeng
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201807557
Subject(s) - nanocapsules , central nervous system , blood–brain barrier , neuroscience , acetylcholine , pharmacology , biology , nanotechnology , materials science , nanoparticle
Central nervous system (CNS) diseases are the leading cause of morbidity and mortality; their treatment, however, remains constrained by the blood–brain barrier (BBB) that impedes the access of most therapeutics to the brain. A CNS delivery platform for protein therapeutics, which is achieved by encapsulating the proteins within nanocapsules that contain choline and acetylcholine analogues, is reported herein. Mediated by nicotinic acetylcholine receptors and choline transporters, such nanocapsules can effectively penetrate the BBB and deliver the therapeutics to the CNS, as demonstrated in mice and non‐human primates. This universal platform, in general, enables the delivery of any protein therapeutics of interest to the brain, opening a new avenue for the treatment of CNS diseases.