Premium
Modular Metal–Organic Polyhedra Superassembly: From Molecular‐Level Design to Targeted Drug Delivery
Author(s) -
Zhu Wei,
Guo Jimin,
Ju Yi,
Serda Rita E.,
Croissant Jonas G.,
Shang Jin,
Coker Eric,
Agola Jacob Ongudi,
Zhong QiZhi,
Ping Yuan,
Caruso Frank,
Brinker C. Jeffrey
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201806774
Subject(s) - nanocages , nanocarriers , nanotechnology , materials science , drug delivery , nanomedicine , targeted drug delivery , supramolecular chemistry , nanoclusters , micelle , homogeneous , nanoparticle , molecule , chemistry , organic chemistry , aqueous solution , catalysis , physics , thermodynamics
Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superassembly of nanosized metal–organic polyhedra (MOP) and their biomimetic coatings of lipid bilayers are described to synergistically combine the advantages of micelles and supramolecular coordination cages for targeted drug delivery. The superassembly technique affords unique hydrophobic features that endow individual MOP to act as nanobuilding blocks and enable their superassembly into larger and well‐defined nanocarriers with homogeneous sizes over a broad range of diameters. Various cargos are controllably loaded into the MOP with high payloads, and the nanocages are then superassembled to form multidrug delivery systems. Additionally, functional nanoparticles are introduced into the superassemblies via a one‐pot process for versatile bioapplications. The MOP superassemblies are surface‐engineered with epidermal growth factor receptors and can be targeted to cancer cells. In vivo studies indicated the assemblies to have a substantial circulation half‐life of 5.6 h and to undergo renal clearance—characteristics needed for nanomedicines.