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Nitric‐Oxide‐Releasing Biomaterial Regulation of the Stem Cell Microenvironment in Regenerative Medicine
Author(s) -
Midgley Adam C.,
Wei Yongzhen,
Li Zongjin,
Kong Deling,
Zhao Qiang
Publication year - 2020
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201805818
Subject(s) - stem cell , regenerative medicine , paracrine signalling , regeneration (biology) , stem cell therapy , microbiology and biotechnology , nitric oxide , biomaterial , tissue engineering , materials science , cell , nanotechnology , biology , medicine , biomedical engineering , biochemistry , receptor
Abstract Stem cell therapy has proven to be an attractive solution for the treatment of degenerative diseases or injury. However, poor cell engraftment and survival within injured tissues limits the successful use of stem cell therapy within the clinical setting. Nitric oxide (NO) is an important signaling molecule involved in various physiological processes. Emerging evidence supports NO's diverse roles in modulating stem cell behavior, including survival, migration, differentiation, and paracrine secretion of proregenerative factors. Thus, there has been a shift in research focus to concentrate efforts on the delivery of therapeutic concentration ranges of NO to the target tissue sites. Combinatory therapies utilizing biomaterials that control NO generation and support stem cell delivery can be holistic and synergistic approaches to significantly improve tissue regeneration. Here, the focus is on recent developments of various therapeutic platforms, engineered to both transport NO and to enhance stem‐cell‐mediated regeneration of damaged tissues. New and emerging revelations of how the stem cell microenvironment can be regulated by NO‐releasing biomaterials are also highlighted.