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Supramolecularly Engineered NIR‐II and Upconversion Nanoparticles In Vivo Assembly and Disassembly to Improve Bioimaging
Author(s) -
Zhao Mengyao,
Li Benhao,
Wang Peiyuan,
Lu Lingfei,
Zhang Zhengcheng,
Liu Lu,
Wang Shangfeng,
Li Dandan,
Wang Rui,
Zhang Fan
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201804982
Subject(s) - materials science , photon upconversion , nanotechnology , in vivo , nanoparticle , nanoprobe , optoelectronics , luminescence , microbiology and biotechnology , biology
Contrast agents for bioimaging suffer from low accumulation at lesion area and high uptake in the reticuloendothelial system (RES). Assembly of nanoparticles in vivo improves their enrichment at tumors and inflamed areas. However, uncontrollable assembly also occurs at the liver and spleen owing to the uptake of nanoparticles by the RES. This is known to probably cause a higher bioimaging background and more severe health hazards, which may hamper the clinical application. Herein, a new near‐infrared (NIR)‐controlled supramolecular engineering strategy is developed for in vivo assembly and disassembly between lanthanide upconversion nanoparticles and second near‐infrared window (NIR‐II, 1000–1700 nm) nanoprobes to realize precision bioimaging of tumors. A supramolecular structure is designed to realize assembly via host–guest interactions of azobenzene and β‐cyclodextrin to enhance the retention of NIR‐II nanoprobes in the tumor area. Meanwhile NIR‐laser‐controllable nanoprobes disassembly brings about a reduction in the bioimaging background as well as acceleration of their RES clearance rate. This strategy may also be used in other nano‐to‐micro‐scale contrast agents to improve bioimaging signal‐to‐noise ratio and reduce long‐term cytotoxicity.