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Rationally Designed DNA‐Origami Nanomaterials for Drug Delivery In Vivo
Author(s) -
Jiang Qiao,
Liu Shaoli,
Liu Jianbing,
Wang ZhenGang,
Ding Baoquan
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201804785
Subject(s) - nanotechnology , dna origami , drug delivery , materials science , nanomaterials , biocompatibility , dna nanotechnology , nanostructure , dna , chemistry , metallurgy , biochemistry
Abstract The recent decades have seen a surge of new nanomaterials designed for efficient drug delivery. DNA nanotechnology has been developed to construct sophisticated 3D nanostructures and artificial molecular devices that can be operated at the nanoscale, giving rise to a variety of programmable functions and fascinating applications. In particular, DNA‐origami nanostructures feature rationally designed geometries and precise spatial addressability, as well as marked biocompatibility, thus providing a promising candidate for drug delivery. Here, the recent successful efforts to employ self‐assembled DNA‐origami nanostructures as drug‐delivery vehicles are summarized. The remaining challenges and open opportunities are also discussed.