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Tactile Chemomechanical Transduction Based on an Elastic Microstructured Array to Enhance the Sensitivity of Portable Biosensors
Author(s) -
Wang Ting,
Qi Dianpeng,
Yang Hui,
Liu Zhiyuan,
Wang Ming,
Leow Wan Ru,
Chen Geng,
Yu Jiancan,
He Ke,
Cheng Hongwei,
Wu YunLong,
Zhang Han,
Chen Xiaodong
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201803883
Subject(s) - biosensor , transduction (biophysics) , nanotechnology , materials science , tactile sensor , microfluidics , tactile perception , signal (programming language) , biomimetics , computer science , neuroscience , biophysics , perception , biology , artificial intelligence , robot , programming language
Tactile sensors capable of perceiving biophysical signals such as force, pressure, or strain have attracted extensive interest for versatile applications in electronic skin, noninvasive healthcare, and biomimetic prostheses. Despite these great achievements, they are still incapable of detecting bio/chemical signals that provide even more meaningful and precise health information due to the lack of efficient transduction principles. Herein, a tactile chemomechanical transduction strategy that enables the tactile sensor to perceive bio/chemical signals is proposed. In this methodology, pyramidal tactile sensors are linked with biomarker‐induced gas‐producing reactions, which transduce biomarker signals to electrical signals in real time. The method is advantageous as it enhances electrical signals by more than tenfold based on a triple‐step signal amplification strategy, as compared to traditional electrical biosensors. It also constitutes a portable and general platform capable of quantifying a wide spectrum of targets including carcinoembryonic antigen, interferon‐γ, and adenosine. Such tactile chemomechanical transduction would greatly broaden the application of tactile sensors toward bio/chemical signals perception which can be used in ultrasensitive portable biosensors and chemical‐responsive chemomechanical systems.