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Magnetic Interaction of Multifunctional Core–Shell Nanoparticles for Highly Effective Theranostics
Author(s) -
Yang MingDa,
Ho ChienHsin,
Ruta Sergiu,
Chantrell Roy,
Krycka Kathryn,
Hovorka Ondrej,
Chen FuRong,
Lai PingShan,
Lai ChihHuang
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201802444
Subject(s) - materials science , superparamagnetism , nanoparticle , magnetic hyperthermia , magnetic nanoparticles , nanotechnology , nuclear magnetic resonance , nanomedicine , magnetic resonance imaging , magnetization , anisotropy , dipole , magnetic field , chemistry , optics , radiology , medicine , physics , organic chemistry , quantum mechanics
The controlled size and surface treatment of magnetic nanoparticles (NPs) make one‐stage combination feasible for enhanced magnetic resonance imaging (MRI) contrast and effective hyperthermia. However, superparamagnetic behavior, essential for avoiding the aggregation of magnetic NPs, substantially limits their performance. Here, a superparamagnetic core–shell structure is developed, which promotes the formation of vortex‐like intraparticle magnetization structures in the remanent state, leading to reduced dipolar interactions between two neighboring NPs, while during an MRI scan, the presence of a DC magnetic field induces the formation of NP chains, introducing increased local inhomogeneous dipole fields that enhance relaxivity. The core–shell NPs also reveal an augmented anisotropy, due to exchange coupling to the high anisotropy core, which enhances the specific absorption rate. This in vivo tumor study reveals that the tumor cells can be clearly diagnosed during an MRI scan and the tumor size is substantially reduced through hyperthermia therapy by using the same FePt@iron oxide nanoparticles, realizing the concept of theranostics.