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The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development
Author(s) -
Sorushanova Anna,
Delgado Luis M.,
Wu Zhuning,
Shologu Naledi,
Kshirsagar Aniket,
Raghunath Rufus,
Mullen Anne M.,
Bayon Yves,
Pandit Abhay,
Raghunath Michael,
Zeugolis Dimitrios I.
Publication year - 2019
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201801651
Subject(s) - biomaterial , regenerative medicine , extracellular matrix , tissue engineering , supramolecular chemistry , nanotechnology , biochemistry , biosynthesis , materials science , computational biology , cell , microbiology and biotechnology , chemistry , biology , biomedical engineering , enzyme , molecule , engineering , organic chemistry
Collagen is the oldest and most abundant extracellular matrix protein that has found many applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview of the family of collagens and their respective structures, conformation, and biosynthesis is provided. The advances and shortfalls of various collagen preparations (e.g., mammalian/marine extracted collagen, cell‐produced collagens, recombinant collagens, and collagen‐like peptides) and crosslinking technologies (e.g., chemical, physical, and biological) are then critically discussed. Subsequently, an array of structural, thermal, mechanical, biochemical, and biological assays is examined, which are developed to analyze and characterize collagenous structures. Lastly, a comprehensive review is provided on how advances in engineering, chemistry, and biology have enabled the development of bioactive, 3D structures (e.g., tissue grafts, biomaterials, cell‐assembled tissue equivalents) that closely imitate native supramolecular assemblies and have the capacity to deliver in a localized and sustained manner viable cell populations and/or bioactive/therapeutic molecules. Clearly, collagens have a long history in both evolution and biotechnology and continue to offer both challenges and exciting opportunities in regenerative medicine as nature's biomaterial of choice.