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Materials and Techniques for Implantable Nutrient Sensing Using Flexible Sensors Integrated with Metal–Organic Frameworks
Author(s) -
Ling Wei,
Liew Guoguang,
Li Ya,
Hao Yafeng,
Pan Huizhuo,
Wang Hanjie,
Ning Baoan,
Xu Hang,
Huang Xian
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201800917
Subject(s) - materials science , metal organic framework , nanotechnology , porosity , electronics , adsorption , electrical engineering , chemistry , organic chemistry , composite material , engineering
The combination of novel materials with flexible electronic technology may yield new concepts of flexible electronic devices that effectively detect various biological chemicals to facilitate understanding of biological processes and conduct health monitoring. This paper demonstrates single‐ or multichannel implantable flexible sensors that are surface modified with conductive metal–organic frameworks (MOFs) such as copper‐MOF and cobalt‐MOF with large surface area, high porosity, and tunable catalysis capability. The sensors can monitor important nutriments such as ascorbicacid, glycine, l ‐tryptophan ( l ‐Trp), and glucose with detection resolutions of 14.97, 0.71, 4.14, and 54.60 × 10 −6 m , respectively. In addition, they offer sensing capability even under extreme deformation and complex surrounding environment with continuous monitoring capability for 20 d due to minimized use of biological active chemicals. Experiments using live cells and animals indicate that the MOF‐modified sensors are biologically safe to cells, and can detect l ‐Trp in blood and interstitial fluid. This work represents the first effort in integrating MOFs with flexible sensors to achieve highly specific and sensitive implantable electrochemical detection and may inspire appearance of more flexible electronic devices with enhanced capability in sensing, energy storage, and catalysis using various properties of MOFs.