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Metal–Organic‐Framework‐Derived Carbon Nanostructure Augmented Sonodynamic Cancer Therapy
Author(s) -
Pan Xueting,
Bai Lixin,
Wang Hui,
Wu Qingyuan,
Wang Hongyu,
Liu Shuang,
Xu Bolong,
Shi Xinghua,
Liu Huiyu
Publication year - 2018
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201800180
Subject(s) - sonodynamic therapy , materials science , nanostructure , porphyrin , nanoparticle , nanotechnology , reactive oxygen species , homo/lumo , metal organic framework , chemical engineering , amorphous carbon , amorphous solid , photochemistry , molecule , organic chemistry , chemistry , biochemistry , adsorption , engineering
Sonodynamic therapy (SDT) can overcome the critical issue of depth‐penetration barrier of photo‐triggered therapeutic modalities. However, the discovery of sonosensitizers with high sonosensitization efficacy and good stability is still a significant challenge. In this study, the great potential of a metal–organic‐framework (MOF)‐derived carbon nanostructure that contains porphyrin‐like metal centers (PMCS) to act as an excellent sonosensitizer is identified. Excitingly, the superior sonosensitization effect of PMCS is believed to be closely linked to the porphyrin‐like macrocycle in MOF‐derived nanostructure in comparison to amorphous carbon nanospheres, due to their large highest occupied molecular orbital (HOMO)–lowest unoccupied molecular orbital (LUMO) gap for high reactive oxygen species (ROS) production. The nanoparticle‐assisted cavitation process, including the visualized formation of the cavitation bubbles and microjets, is also first captured by high‐speed camera. High ROS production in PMCS under ultrasound is validated by electron spin resonance and dye measurement, followed by cellular destruction and high tumor inhibition efficiency (85%). This knowledge is important from the perspective of understanding the structure‐dependent SDT enhancement of a MOF‐derived carbon nanostructure.